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Article

A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.

PLoS biology - 1 Jan 2012

Wollam Joshua, Magner Daniel B, Magomedova Lilia, Rass Elisabeth, Shen Yidong, Rottiers Veerle, Habermann Bianca, Cummins Carolyn L, Antebi Adam

Abstract excerpt

Endogenous small molecule metabolites that regulate animal longevity are emerging as a novel means to influence health and life span. In C. elegans, bile acid-like steroids called the dafachronic acids (DAs) regulate developmental timing and longevity through the conserved nuclear hormone receptor DAF-12, a homolog of mammalian sterol-regulated receptors LXR and FXR. Using metabolic genetics, mass spectrometry,...

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Identifiers

PMID: 22505847
DOI: 10.1371/journal.pbio.1001305
PMCID: PMC3323522

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