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Article

Structural and sequencing analysis of local target DNA recognition by MLV integrase.

Nucleic acids research - 23 Jun 2015

Aiyer Sriram, Rossi Paolo, Malani Nirav, Schneider William M, Chandar Ashwin, Bushman Frederic D, Montelione Gaetano T, Roth Monica J

Abstract excerpt

Target-site selection by retroviral integrase (IN) proteins profoundly affects viral pathogenesis. We describe the solution nuclear magnetic resonance structure of the Moloney murine leukemia virus IN (M-MLV) C-terminal domain (CTD) and a structural homology model of the catalytic core domain (CCD). In solution, the isolated MLV IN CTD adopts an SH3 domain fold flanked by a C-terminal unstructured tail. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25969444
DOI: 10.1093/nar/gkv410
PMCID: PMC4477651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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