The DNA-binding domain of HIV-1 integrase has an SH3-like fold.

doi:10.1038/nsb0995-807

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Article

The DNA-binding domain of HIV-1 integrase has an SH3-like fold.

Nature structural biology - 1 Sept 1995

Eijkelenboom A P, Lutzke R A, Boelens R, Plasterk R H, Kaptein R, Hård K

Abstract excerpt

We have determined the solution structure of the DNA-binding domain of HIV-1 integrase by nuclear magnetic resonance spectroscopy. In solution, this carboxyterminal region of integrase forms a homodimer, consisting of two structures that closely resemble Src-homology 3 (SH3) domains. Lys 264, pre...

Topics

Amino Acid Sequence
Binding Sites
Chromatography, Gel
DNA
DNA Nucleotidyltransferases
HIV-1
Integrases
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Mutation
Protein Conformation
Protein Folding
Sequence Homology, Amino Acid
src Homology Domains

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Open in PubMed

Identifiers

PMID: 7552753
DOI: 10.1038/nsb0995-807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7552753-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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