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Article

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.

Nucleic acids research - 1 Apr 2014

Serrao Erik, Krishnan Lavanya, Shun Ming-Chieh, Li Xiang, Cherepanov Peter, Engelman Alan, Maertens Goedele N

Abstract excerpt

Retroviruses favor target-DNA (tDNA) distortion and particular bases at sites of integration, but the mechanism underlying HIV-1 selectivity is unknown. Crystal structures revealed a network of prototype foamy virus (PFV) integrase residues that distort tDNA: Ala188 and Arg329 interact with tDNA bases, while Arg362 contacts the phosphodiester backbone. HIV-1 integrase residues Ser119, Arg231, and Lys258 were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24520116
DOI: 10.1093/nar/gku136
PMCID: PMC4005685

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