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Article

Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis.

PloS one - 1 Jan 2011

Peletskaya Elena, Andrake Mark, Gustchina Alla, Merkel George, Alexandratos Jerry, Zhou Dongwen, Bojja Ravi S, Satoh Tadashi, Potapov Mikhail, Kogon Alex, Potapov Viktor, Wlodawer Alexander, Skalka Anna Marie

Abstract excerpt

BACKGROUND: We applied crosslinking techniques as a first step in preparation of stable avian sarcoma virus (ASV) integrase (IN)-DNA complexes for crystallographic investigations. These results were then compared with the crystal structures of the prototype foamy virus (PFV) intasome and with published data for other retroviral IN proteins. METHODOLOGY/RESULTS: Photoaffinity crosslinking and site-directed...

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Share to Avian Sarcoma Viruses
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to DNA, Viral

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

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Identifiers

PMID: 22145019
DOI: 10.1371/journal.pone.0027751
PMCID: PMC3228729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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