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Article

Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of TNF-308G>A variant with type 1 diabetes in a Brazilian cohort.

Gene - 15 Aug 2015

Patente Thiago A, Monteiro Maria B, Vieira Suzana M, Rossi da Silva Maria E, Nery Márcia, Queiroz Márcia, Azevedo Mirela J, Canani Luis H, Parisi Maria C, Pavin Elizabeth J, Mainardi Débora, Javor Juraj, Velho Gilberto, Coimbra Cássio N, Corrêa-Giannella Maria Lúcia

Abstract excerpt

BACKGROUND: A functional variant in the promoter region of the gene encoding tumor necrosis factor (TNF; rs1800629, -308G>A) showed to confer susceptibility to T1D. However, TNF rs1800629 was found, in several populations, to be in linkage disequilibrium with HLA susceptibility haplotypes to T1D. We evaluated the association of TNF rs1800629 with T1D in a cohort of Brazilian subjects, and assessed the impact of...

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Share to Brazil
Share to Diabetes Mellitus, Type 1
Share to Genes, Dominant
Share to Genetic Association Studies
Share to HLA-DQ beta-Chains
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Share to Linkage Disequilibrium
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Source

Identifiers

PMID: 25965561
DOI: 10.1016/j.gene.2015.05.017

Genes

TNF

Variants

rs1800629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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