Article
Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population.
Biological research - 1 Jan 2008
Boraska Vesna, Skrabić Veselin, Culić Vedrana Cikes, Becić Kristijan, Kapitanović Sanja, Zemunik Tatijana
Abstract excerpt
Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction of pancreatic p cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent immunomodulatory and inflammatory activity. Association studies of TNF polymorphisms and type 1 diabetes (TIDM) frequently demonstrated TNF involvement with TIDM. Although TNF may play an important role in the pathogenesis of TIDM, the...
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