Article
TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ.
Human immunology - 1 Aug 2007
Aminkeng Folefac, Van Autreve Jan E, Koeleman Bobby P C, Quartier Erik, Van Schravendijk Chris, Gorus Frans K, Van der Auwera Bart J R
Abstract excerpt
To determine the contribution of the tumor necrosis factor alpha gene (TNFA) to the immunogenetic risk prediction of type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients with type 1 diabetes (T1D), nondiabetic control subjects, and nuclear families were analyzed for HLA-DQA1-DQB1, TNFA -308 G/A promoter single nucleotide polymorphism (SNP) and TNFa microsatellite markers...
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