Article

Mitochondrial Raf1 Regulates Glutamine Catabolism

2024-03-09

Abstract excerpt

<h4>One-Sentence Summary</h4> Raf1 is present within the mitochondrial matrix, where it binds GLS to regulate glutamine catabolism and tumorigenesis. In cancer, Raf1 activation occurs via mechanisms that include mutation of upstream regulators, such as receptor tyrosine kinases and Ras GTPases, as well as by mutations that affect RAF1 itself, including via gene amplification ( 1 – 4 ). Once recruited to the pl...

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Literature Corpus work: fa70f949-02c8-5e7e-bac1-f6c657caac90
DOI: 10.1101/2024.03.08.581297

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