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Article

Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2015

Gale Rosemary E, Lamb Katarina, Allen Christopher, El-Sharkawi Dima, Stowe Cassandra, Jenkinson Sarah, Tinsley Steven, Dickson Glenda, Burnett Alan K, Hills Robert K, Linch David C

Abstract excerpt

PURPOSE: To evaluate the impact of DNMT3A mutations on outcome in younger patients with cytogenetic intermediate-risk acute myeloid leukemia. PATIENTS AND METHODS: Diagnostic samples from 914 patients (97% < 60 years old) were screened for mutations in DNMT3A exons 13 to 23. Clinical outcome was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25964253
DOI: 10.1200/JCO.2014.59.2022

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25964253-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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