Article
Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry.
Familial cancer - 1 Sept 2012
Pande Mala, Wei Chongjuan, Chen Jinyun, Amos Christopher I, Lynch Patrick M, Lu Karen H, Lucio Laura A, Boyd-Rogers Stephanie G, Bannon Sarah A, Mork Maureen E, Frazier Marsha L
Abstract excerpt
The spectrum of cancers seen in a hospital based Lynch syndrome registry of mismatch repair gene mutation carriers was examined to determine the distribution of cancers and examine excess cancer risk. Overall there were 504 cancers recorded in 368 mutation carriers from 176 families. These included 236 (46.8 %) colorectal and 268 (53.2 %) extracolonic cancers. MLH1 mutation carriers had a higher frequency of...
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