Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.

doi:10.1038/nm.3840

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Article

Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.

Nature medicine - 1 Jun 2015

Li Benshang, Li Hui, Bai Yun, Kirschner-Schwabe Renate, Yang Jun J, Chen Yao, Lu Gang, Tzoneva Gannie, Ma Xiaotu, Wu Tongmin, Li Wenjing, Lu Haisong, Ding Lixia, Liang Huanhuan, Huang Xiaohang, Yang Minjun, Jin Lei, Kang Hui, Chen Shuting, Du Alicia, Shen Shuhong, Ding Jianping, Chen Hongzhuan, Chen Jing, von Stackelberg Arend, Gu Longjun, Zhang Jinghui, Ferrando Adolfo, Tang Jingyan, Wang Shengyue, Zhou Bin-Bing S

Abstract excerpt

Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which encodes a rate-limiting purine biosynthesis enzyme, in 24/358 (6.7%) relapsed childhood B cell ALL...

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PMID: 25962120
DOI: 10.1038/nm.3840
PMCID: PMC4670083

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PRPS1

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