Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thiopurine Resistance in Childhood ALL Is Mediated by PRPS1 Mutations.

Cancer discovery - 1 Jul 2015

Abstract excerpt

Mutations in the de novo purine biosynthesis enzyme PRPS1 drive thiopurine resistance in relapsed ALL.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Neoplasm
Share to Mercaptopurine
Share to Mutation
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prodrugs

Share to Thioguanine

Source

Identifiers

PMID: 25998402
DOI: 10.1158/2159-8290.CD-RW2015-095

Genes

PRPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thiopurine Resistance in Childhood ALL Is Mediated by PRPS1 Mutations.PMID 25998402Read ↗

Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.Semantic proximity Read ↗

In silico identification of deleterious NT5C2 and PRPS1 mutations driving thiopurine resistance in relapsed acute lymphoblastic leukemia.Semantic proximity Read ↗

Acquired thiopurine resistance and mismatch repair aberrations in paediatric B-cell acute lymphoblastic leukaemia relapse: A real-world data integrating mutational signatures, clones and clinical thiopurine dosing patterns.Semantic proximity Read ↗

CRISPR/Cas9-Mediated Induction of Relapse-Specific NT5C2 and PRPS1 Mutations Confers Thiopurine Resistance as a Relapsed Lymphoid Leukemia Model.Semantic proximity Read ↗

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets.Semantic proximity Read ↗

FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.Semantic proximity Read ↗

Feasibility of monitoring peripheral blood to detect emerging clones in children with acute lymphoblastic leukemia†.Semantic proximity Read ↗

A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALLSemantic proximity Read ↗

Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.Semantic proximity Read ↗

Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALLSemantic proximity Read ↗

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMTSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.