Article
FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia.
Scientific reports - 21 Jul 2020
Yu Sung-Liang, Zhang Hui, Ho Bing-Ching, Yu Chih-Hsiang, Chang Chia-Ching, Hsu Yin-Chen, Ni Yu-Ling, Lin Kai-Hsin, Jou Shiann-Tarng, Lu Meng-Yao, Chen Shu-Huey, Wu Kang-Hsi, Wang Shih-Chung, Chang Hsiu-Hao, Pui Ching-Hon, Yang Jun J, Zhang Jinghui, Lin Dong-Tsamn, Lin Shu-Wha, Ma Xiaotu, Yang Yung-Li
Abstract excerpt
Although the cure rate for childhood acute lymphoblastic leukemia (ALL) has exceeded 80% with contemporary therapy, relapsed ALL remains a leading cause of cancer-related death in children. Relapse-specific mutations can be identified by comprehensive genome sequencing and might have clinical significance. Applying whole-exome sequencing to eight triplicate samples, we identified in one patient relapse-specific...
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