Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of pneumococcal colonization determinants in the stringent response pathway facilitated by genomic diversity.

BMC genomics - 9 May 2015

Li Yuan, Croucher Nicholas J, Thompson Claudette M, Trzciński Krzysztof, Hanage William P, Lipsitch Marc

Abstract excerpt

BACKGROUND: Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest, but the naturally existing genomic and phenotypic diversity of microbial populations has rarely been exploited. Here we report use of a diverse collection of 616 carriage isolates of Streptococcus pneumoniae and their genome sequences to help...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Fitness
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Bacterial

Share to Genomics

Share to Polymorphism, Single Nucleotide

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 25956132
DOI: 10.1186/s12864-015-1573-6
PMCID: PMC4424882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of pneumococcal colonization determinants in the stringent response pathway facilitated by genomic diversity.PMID 25956132Read ↗

Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease.Semantic proximity Read ↗

LacR and TrxB are key virulence factors involved in pneumococcal meningitis as identified by a genome-wide association studySemantic proximity Read ↗

Identification of colonisation and virulence determinants of <i>Streptococcus pneumoniae</i> via experimental evolution in mouse infection modelsSemantic proximity Read ↗

Streptococcus pneumoniae: virulence factors and variation.Semantic proximity Read ↗

Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.Semantic proximity Read ↗

Virulence factors in pneumococcal respiratory pathogenesis.Semantic proximity Read ↗

Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.Semantic proximity Read ↗

Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors.Semantic proximity Read ↗

Pneumococcal Capsule Synthesis Locus cps as Evolutionary Hotspot with Potential to Generate Novel Serotypes by Recombination.Semantic proximity Read ↗

Streptococcus pyogenes genes that promote pharyngitis in primatesSemantic proximity Read ↗

Influence of Streptococcus pneumoniae Within-Strain Population Diversity on Virulence and Pathogenesis.Semantic proximity Read ↗

Pneumococcal Colonization and Virulence Factors Identified Via Experimental Evolution in Infection ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.