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Article

Pneumococcal Capsule Synthesis Locus cps as Evolutionary Hotspot with Potential to Generate Novel Serotypes by Recombination.

Molecular biology and evolution - 1 Oct 2017

Mostowy Rafal J, Croucher Nicholas J, De Maio Nicola, Chewapreecha Claire, Salter Susannah J, Turner Paul, Aanensen David M, Bentley Stephen D, Didelot Xavier, Fraser Christophe

Abstract excerpt

Diversity of the polysaccharide capsule in Streptococcus pneumoniae-main surface antigen and the target of the currently used pneumococcal vaccines-constitutes a major obstacle in eliminating pneumococcal disease. Such diversity is genetically encoded by almost 100 variants of the capsule biosynthesis locus, cps. However, the evolutionary dynamics of the capsule remains not fully understood. Here, using genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28595308
DOI: 10.1093/molbev/msx173
PMCID: PMC5850285

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