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Article

Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.

The Journal of clinical investigation - 1 May 2011

Carroll Ronan K, Shelburne Samuel A, Olsen Randall J, Suber Bryce, Sahasrabhojane Pranoti, Kumaraswami Muthiah, Beres Stephen B, Shea Patrick R, Flores Anthony R, Musser James M

Abstract excerpt

Infection with different strains of the same species of bacteria often results in vastly different clinical outcomes. Despite extensive investigation, the genetic basis of microbial strain-specific virulence remains poorly understood. Recent whole-genome sequencing has revealed that SNPs are the most prevalent form of genetic diversity among different strains of the same species of bacteria. For invasive serotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21490401
DOI: 10.1172/JCI45169
PMCID: PMC3083769

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