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Article

Mutant GNAQ promotes cell viability and migration of uveal melanoma cells through the activation of Notch signaling.

Oncology reports - 1 Jul 2015

Liu Honglei, Lei Chunling, Long Keqin, Yang Xinguang, Zhu Zhaoliang, Zhang Lihua, Liu Jun

Abstract excerpt

The occurrence of guanine nucleotide binding protein (G protein), q polypeptide (GNAQ) mutations has been found to be high in the majority of uveal melanomas. However, the underlying molecular mechanism of GNAQ mutations in modulating uveal melanoma is poorly understood. The aim of the present study was to investigate the role and underlying mechanism of mutant GNAQ in the regulation of cell viability and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25955651
DOI: 10.3892/or.2015.3949

Genes

GNAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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