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Article

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.

Molecular cancer research : MCR - 1 May 2017

Chua Vivian, Lapadula Dominic, Randolph Clinita, Benovic Jeffrey L, Wedegaertner Philip B, Aplin Andrew E

Abstract excerpt

Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease. The liver is the predominant organ of metastasis. There is an important need to provide effective treatment options for advanced stage uveal melanoma. To provide the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28223438
DOI: 10.1158/1541-7786.MCR-17-0007
PMCID: PMC5468095

Genes

GNA11
GNAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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