Article
Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2021
Hitchman Tyler D, Bayshtok Gabriella, Ceraudo Emilie, Moore Amanda R, Lee Cindy, Jia Ruobing, Wang Naitao, Pachai Mohini R, Shoushtari Alexander N, Francis Jasmine H, Guan Youxin, Chen Juliet, Chang Matthew T, Taylor Barry S, Sakmar Thomas P, Huber Thomas, Chi Ping, Chen Yu
Abstract excerpt
PURPOSE: All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the G-protein alpha-q (Gαq) pathway. Targeting these melanomas has proven difficult despite advances in the molecular understanding of key driver signaling pathways in the disease pathogenesis. Inhibitors of Gαq have shown promising preclinical results, but their therapeutic activity in distinct Gαq mutational...
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