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Article

Gq/G11 oncogenic mutations promote PD-L1 expression and suppress tumor immunity.

European journal of cell biology - 1 Dec 2024

Dong Jingyan, Xu Yue, Yu Dawei, Zhang Xiaoling, Wang Anqi, Lv Lei, Li Zhiqing

Abstract excerpt

Uveal melanoma (UM) is the predominant form of eye cancer. The genes GNAQ and GNA11, encoding Gq and G11 respectively, are most frequently mutated in UM and are considered the major drivers of UM carcinogenesis by activating YAP. However, the mechanisms by which metastatic UM evades the immune system remain poorly understood. In this study, we found that oncogenic mutations of Gq/G11 promoted YAP and PD-L1...

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Share to B7-H1 Antigen
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Identifiers

PMID: 39550833
DOI: 10.1016/j.ejcb.2024.151467

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