Article
Detection of GNAQ mutations and reduction of cell viability in uveal melanoma cells with functionalized gold nanoparticles.
Biomedical microdevices - 1 Feb 2015
Posch Christian, Latorre Alfonso, Crosby Michelle B, Celli Anna, Latorre Ana, Vujic Igor, Sanlorenzo Martina, Green Gary A, Weier Jingly, Zekhtser Mitchell, Ma Jeffrey, Monico Gabriela, Char Devron H, Jusufbegovic Denis, Rappersberger Klemens, Somoza Álvaro, Ortiz-Urda Susana
Abstract excerpt
BACKGROUND: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Early treatment may improve any chances of preventing metastatic disease, but diagnosis of small UM is challenging. Up to 95 % of all UMs carry somatic mutations in the G-coupled proteins GNAQ and GNA11 promoting anchorage-independent growth and proliferation. About 50 % of UMs are fatal. Once metastatic, patients have...
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