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Article

A Model for p38MAPK-Induced Astrocyte Senescence.

PloS one - 1 Jan 2015

Mombach José C M, Vendrusculo Bruno, Bugs Cristhian A

Abstract excerpt

Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and diseases. Recent results have showed that markers of senescence in astrocytes from aged brains are increased in brains with Alzheimer's disease. These studies...

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Identifiers

PMID: 25954815
DOI: 10.1371/journal.pone.0125217
PMCID: PMC4425668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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