Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two possible definitions?

doi:10.1100/tsw.2002.100

Article

Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two possible definitions?

TheScientificWorldJournal - 29 Jan 2002

Toussaint Olivier, Dumont Patrick, Remacle José, Dierick Jean-François, Pascal Thierry, Frippiat Christophe, Magalhaes Joao Pedro, Zdanov Stéphanie, Chainiaux Florence

Abstract excerpt

No consensus exists so far on the definition of cellular senescence. The narrowest definition of senescence is irreversible growth arrest triggered by telomere shortening counting cell generations (definition 1). Other authors gave an enlarged functional definition encompassing any kind of irreversible arrest of proliferative cell types induced by damaging agents or cell cycle deregulations after overexpression...

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Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two possible definitions?

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