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Article

Mutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer.

Aging - 5 Oct 2016

Kalsbeek Anton M F, Chan Eva F K, Grogan Judith, Petersen Desiree C, Jaratlerdsiri Weerachai, Gupta Ruta, Lyons Ruth J, Haynes Anne-Maree, Horvath Lisa G, Kench James G, Stricker Phillip D, Hayes Vanessa M

Abstract excerpt

Prostate cancer management is complicated by extreme disease heterogeneity, which is further limited by availability of prognostic biomarkers. Recognition of prostate cancer as a genetic disease has prompted a focus on the nuclear genome for biomarker discovery, with little attention given to the mitochondrial genome. While it is evident that mitochondrial DNA (mtDNA) mutations are acquired during prostate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27705925
DOI: 10.18632/aging.101044
PMCID: PMC5191864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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