Article
Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment.
The Prostate - 1 Jan 2009
Arnold Rebecca S, Sun Carrie Q, Richards Jendai C, Grigoriev Galina, Coleman Ilsa M, Nelson Peter S, Hsieh Chia-Ling, Lee Jae K, Xu Zhiheng, Rogatko Andre, Osunkoya Adeboye O, Zayzafoon Majd, Chung Leland, Petros John A
Abstract excerpt
BACKGROUND AND OBJECTIVES: Mitochondrial DNA (mtDNA) mutations, inherited and somatically acquired, are common in clinical prostate cancer. We have developed model systems designed to study specific mtDNA mutations in controlled experiments. Because prostate cancer frequently metastasizes to bone we tested the hypothesis that mtDNA mutations enhance prostate cancer growth and survival in the bone...
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