Article
Performance of a blockwise approach in variable selection using linkage disequilibrium information.
BMC bioinformatics - 8 May 2015
Dehman Alia, Ambroise Christophe, Neuvial Pierre
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) aim at finding genetic markers that are significantly associated with a phenotype of interest. Single nucleotide polymorphism (SNP) data from the entire genome are collected for many thousands of SNP markers, leading to high-dimensional regression problems where the number of predictors greatly exceeds the number of observations. Moreover, these predictors are...
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