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Article

A variable selection method for genome-wide association studies.

Bioinformatics (Oxford, England) - 1 Jan 2011

He Qianchuan, Lin Dan-Yu

Abstract excerpt

MOTIVATION: Genome-wide association studies (GWAS) involving half a million or more single nucleotide polymorphisms (SNPs) allow genetic dissection of complex diseases in a holistic manner. The common practice of analyzing one SNP at a time does not fully realize the potential of GWAS to identify multiple causal variants and to predict risk of disease. Existing methods for joint analysis of GWAS data tend to miss...

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PMID: 21036813
DOI: 10.1093/bioinformatics/btq600
PMCID: PMC3025714

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