Article
A new haplotype block detection method for dense genome sequencing data based on interval graph modeling of clusters of highly correlated SNPs.
Bioinformatics (Oxford, England) - 1 Feb 2018
Kim Sun Ah, Cho Chang-Sung, Kim Suh-Ryung, Bull Shelley B, Yoo Yun Joo
Abstract excerpt
Motivation: Linkage disequilibrium (LD) block construction is required for research in population genetics and genetic epidemiology, including specification of sets of single nucleotide polymorphisms (SNPs) for analysis of multi-SNP based association and identification of haplotype blocks in high density sequencing data. Existing methods based on a narrow sense definition do not allow intermediate regions of low...
Topics
- Algorithms
- Asian People
- Genetics, Population
- Genome, Human
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA