Article
Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance.
PLoS pathogens - 1 May 2015
Reed Patricia, Atilano Magda L, Alves Renato, Hoiczyk Egbert, Sher Xinwei, Reichmann Nathalie T, Pereira Pedro M, Roemer Terry, Filipe Sérgio R, Pereira-Leal José B, Ligoxygakis Petros, Pinho Mariana G
Abstract excerpt
Many important cellular processes are performed by molecular machines, composed of multiple proteins that physically interact to execute biological functions. An example is the bacterial peptidoglycan (PG) synthesis machine, responsible for the synthesis of the main component of the cell wall and the target of many contemporary antibiotics. One approach for the identification of essential components of a cellular...
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