Multiomic data analyses unveiled a novel phenol-soluble modulin that induces trapping of extracellular lipases at the surface of Staphylococcus aureus cells.

Abstract excerpt

Small proteins encoded by small open reading frames are often overlooked by annotation algorithms and consequently missing from genome databases. Here, by combining multiomic approaches, we found 27 novel small proteins in Staphylococcus aureus, one of the most relevant pathogens worldwide. To better understand the importance of small proteins associated with S. aureus virulence factors, we focused on two small...

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