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Article

Evidence for a dual role of PBP1 in the cell division and cell separation of Staphylococcus aureus.

Molecular microbiology - 1 May 2009

Pereira Sandro F F, Henriques Adriano O, Pinho Mariana G, de Lencastre Herminia, Tomasz Alexander

Abstract excerpt

Penicillin-binding proteins (PBPs) catalyse the synthesis of cell wall peptidoglycan. PBP1 of Staphylococcus aureus is a high-molecular-weight monofunctional transpeptidase (TPase) and previous studies with a conditional mutant showed that this protein was essential for bacterial growth and survival: cells in which PBP1 was depleted stopped dividing but continued to enlarge in size, accompanied by rapid loss of...

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Identifiers

PMID: 19400776
DOI: 10.1111/j.1365-2958.2009.06687.x
PMCID: PMC2771448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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