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Article

The Susceptibilities of Human Ether-à-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors.

Biological & pharmaceutical bulletin - 1 Jan 2015

Hisajima Nozomi, Hata Yukiko, Kinoshita Koshi, Fukushima Toshiki, Nishida Naoki, Kano Masanobu, Tabata Toshihide

Abstract excerpt

The human ether-à-go-go-related gene (hERG) channel mediates the rapid delayed rectifier potassium current (IKr) responsible for shaping the repolarization phase of cardiac action potentials. hERG mutation may cause hERG channel malfunction, leading to long QT syndrome and other arrhythmic disorders. Elucidation of the genotype-phenotype relationships of individual hERG mutations is key to the development of...

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Identifiers

PMID: 25947924
DOI: 10.1248/bpb.b14-00630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Susceptibilities of Human Ether-à-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors.PMID 25947924Read ↗

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