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Article

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2004

Anson Blake D, Ackerman Michael J, Tester David J, Will Melissa L, Delisle Brian P, Anderson Corey L, January Craig T

Abstract excerpt

Long QT syndrome (LQTS) is a cardiac repolarization disorder that can lead to arrhythmias and sudden death. Chromosome 7-linked inherited LQTS (LQT2) is caused by mutations in human ether-a-go-go-related gene (HERG; KCNH2), whereas drug-induced LQTS is caused primarily by HERG channel block. Many common polymorphisms are functionally silent and have been traditionally regarded as benign and without physiological...

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Source

Identifiers

PMID: 14975928
DOI: 10.1152/ajpheart.00891.2003

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.PMID 14975928Read ↗

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