Article
Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel.
Circulation - 19 Feb 2002
Moss Arthur J, Zareba Wojciech, Kaufman Elizabeth S, Gartman Eric, Peterson Derick R, Benhorin Jesaia, Towbin Jeffrey A, Keating Mark T, Priori Silvia G, Schwartz Peter J, Vincent G Michael, Robinson Jennifer L, Andrews Mark L, Feng Changyong, Hall W Jackson, Medina Aharon, Zhang Li, Wang Zhiqing
Abstract excerpt
BACKGROUND: The hereditary long-QT syndrome is characterized by prolonged ventricular repolarization and a variable clinical course with arrhythmia-related syncope and sudden death. Mutations involving the human ether-a-go-go-related gene (HERG) channel are responsible for the LQT2 form of long-QT syndrome, and in cellular expression studies these mutations are associated with reduction in the rapid component of...
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