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Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy

5 May 2015

Abstract excerpt

Oxidative stress-induced mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage in peripheral neurons is considered to be important in the development of diabetic neuropathy. Mitochondrial transcription factor A (TFAM) wraps mtDNA and promotes mtDNA replication and transcription. We studied whether overexpression of TFAM reverses experimental peripheral diabetic neuropathy using TFAM transgenic mice (TFAM...

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PMID: 25944881
DOI: 10.1152/ajpendo.00620.2014

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