Article
Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats.
Experimental neurology - 1 Nov 2017
Aghanoori Mohamad-Reza, Smith Darrell R, Roy Chowdhury Subir, Sabbir Mohammad Golam, Calcutt Nigel A, Fernyhough Paul
Abstract excerpt
Diabetic neuropathy affects approximately 50% of diabetic patients. Down-regulation of mitochondrial gene expression and function has been reported in both human tissues and in dorsal root ganglia (DRG) from animal models of type 1 and type 2 diabetes. We hypothesized that loss of direct insulin signaling in diabetes contributes to loss of mitochondrial function in DRG neurons and to development of neuropathy....
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