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Peripheral Blood Mitochondrial DNA Damage as a Potential Noninvasive Biomarker of Diabetic Retinopathy

5 Aug 2016

Abstract excerpt

PURPOSE: In the development of diabetic retinopathy, retinal mitochondria become dysfunctional, and mitochondrial DNA (mtDNA) is damaged. Because retinopathy is a progressive disease, and circulating glucose levels are high in diabetes, our aim was to investigate if peripheral blood mtDNA damage can serve as a potential biomarker of diabetic retinopathy. METHODS: Peripheral blood mtDNA damage was investigated by...

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PMID: 27494345
DOI: 10.1167/iovs.16-19073

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