Article
Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes.
Brain : a journal of neurology - 1 Jun 2012
Roy Chowdhury Subir K, Smith Darrell R, Saleh Ali, Schapansky Jason, Marquez Alexandra, Gomes Suzanne, Akude Eli, Morrow Dwane, Calcutt Nigel A, Fernyhough Paul
Abstract excerpt
Mitochondrial dysfunction occurs in sensory neurons and may contribute to distal axonopathy in animal models of diabetic neuropathy. The adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) signalling axis senses the metabolic d...
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