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Mitochondrial Genome–Encoded Long Noncoding RNA and Mitochondrial Stability in Diabetic Retinopathy

23 Dec 2022

Abstract excerpt

Mitochondria experience genomic and functional instability in diabetes, and mitochondrial dysfunction has a critical role in the development of diabetic retinopathy. Diabetes also alters expressions of many long noncoding RNAs (LncRNAs), the RNAs with >200 nucleotides and no open reading frame. LncRNAs are mainly encoded by the nuclear genome, but mtDNA also encodes three LncRNAs. Our goal was to investigate the...

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PMID: 36563021
DOI: 10.2337/db22-0744

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