Article
Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 2011
Fox Raymond, Kim Hyung-Suk, Reddick Robert L, Kujoth Gregory C, Prolla Tomas A, Tsutsumi Shuichi, Wada Youichiro, Smithies Oliver, Maeda Nobuyo
Abstract excerpt
Diabetes and the development of its complications have been associated with mitochondrial DNA (mtDNA) dysfunction, but causal relationships remain undetermined. With the objective of testing whether increased mtDNA mutations exacerbate the diabetic phenotype, we have compared mice heterozygous for the Akita diabetogenic mutation (Akita) with mice homozygous for the D257A mutation in mitochondrial DNA polymerase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.