Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance.

doi:10.1084/jem.20141731

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Article

Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance.

The Journal of experimental medicine - 1 Jun 2015

Lin Jing-Wen, Spaccapelo Roberta, Schwarzer Evelin, Sajid Mohammed, Annoura Takeshi, Deroost Katrien, Ravelli Raimond B G, Aime Elena, Capuccini Barbara, Mommaas-Kienhuis Anna M, O'Toole Tom, Prins Frans, Franke-Fayard Blandine M D, Ramesar Jai, Chevalley-Maurel Séverine, Kroeze Hans, Koster Abraham J, Tanke Hans J, Crisanti Andrea, Langhorne Jean, Arese Paolo, Van den Steen Philippe E, Janse Chris J, Khan Shahid M

Abstract excerpt

Most studies on malaria-parasite digestion of hemoglobin (Hb) have been performed using P. falciparum maintained in mature erythrocytes, in vitro. In this study, we examine Plasmodium Hb degradation in vivo in mice, using the parasite P. berghei, and show that it is possible to create mutant parasites lacking enzymes involved in the initial steps of Hb proteolysis. These mutants only complete development in...

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PMID: 25941254
DOI: 10.1084/jem.20141731
PMCID: PMC4451122

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