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Article

Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.

Blood - 15 Jan 2015

Smith Clare M, Jerkovic Ante, Puy Hervé, Winship Ingrid, Deybach Jean-Charles, Gouya Laurent, van Dooren Giel, Goodman Christopher Dean, Sturm Angelika, Manceau Hana, McFadden Geoffrey Ian, David Peter, Mercereau-Puijalon Odile, Burgio Gaétan, McMorran Brendan J, Foote Simon J

Abstract excerpt

Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. Erythrocytes from individuals with erythropoietic protoporphyria (EPP) have low levels of the final enzyme in the heme biosynthetic pathway, ferrochelatase. Cells from these patients are resistant to the...

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Share to Erythrocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malaria, Falciparum

Share to Mice, Inbred C57BL

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Share to Protoporphyria, Erythropoietic

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Identifiers

PMID: 25414439
DOI: 10.1182/blood-2014-04-567149
PMCID: PMC4296013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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