Article
Tumour exosomes from cells harbouring PTPRZ1-MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma.
Oncogene - 21 Sept 2017
Zeng A-L, Yan W, Liu Y-W, Wang Z, Hu Q, Nie E, Zhou X, Li R, Wang X-F, Jiang T, You Y-P
Abstract excerpt
Exosomes are carriers of pro-tumorigenic factors that participate in glioblastoma (GBM) progression, and many fusion genes are strong driver mutations in neoplasia and are involved in tumorigenesis. However, the ability of fusion genes to be transduced by exosomes is unknown. We characterized exosomes from GBM cells harbouring and not harbouring PTPRZ1-MET fusion (ZM fusion). We also determined the effect of the...
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