Article

Repurposing passenger amplifications as Trojan horses identifies MPZL1 as a potent target for solid cancers

2025-09-20

Abstract excerpt

Personalized cancer therapies focus mostly on targeting driver alterations, such as oncogenic point mutations or oncogenic driver events within large somatic copy number alterations. However, these alterations are often not actionable or only present in a small subset of patients. We hypothesized that passenger events, specifically in amplified regions, could be therapeutically exploited by providing actionable mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5588206e-e387-56e0-9206-f9c0f710f335
DOI: 10.1101/2025.09.17.675062

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurposing passenger amplifications as Trojan horses identifies MPZL1 as a potent target for solid cancersDOI 10.1101/2025.09.17.675062Read

Pan-cancer analysis of PDZK1IP1 reveals its role in tumorigenesis and tumor immunity: focused validation in thyroid carcinoma.Semantic proximity Read

High‐sensitive clinical diagnostic method for PTPRZ1‐MET and the characteristic protein structure contributing to ligand‐independent MET activationSemantic proximity Read

Met–HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cellsSemantic proximity Read

Met-HER3 crosstalk supports proliferation via MPZL3 in <i>MET</i> -amplified cancer cellsSemantic proximity Read

Harnessing tumor-agnostic biomarkers for precision medicine in lymphoma.Semantic proximity Read

A pan-cancer analysis of PD-L1 immunohistochemistry and gene amplification, tumor mutation burden and microsatellite instability in 48,782 cases.Semantic proximity Read

Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival.Semantic proximity Read

Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCLSemantic proximity Read

A pan-cancer analysis of the oncogenic role of Golgi transport 1B in human tumorsSemantic proximity Read

Enhanced expression and phosphorylation of the MET oncoprotein by glioma‐specific PTPRZ1–MET fusionsSemantic proximity Read

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastomaSemantic proximity Read

Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumorsSemantic proximity Read