Article
Polymorphisms Falling Within Putative miRNA Target Sites in the 3'UTR Region of SIRT2 and DRD2 Genes Are Correlated With Human Longevity.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2016
Crocco Paolina, Montesanto Alberto, Passarino Giuseppe, Rose Giuseppina
Abstract excerpt
Many studies have suggested that individual differences in aging phenotypes may be associated to polymorphisms affecting gene regulation. As single-nucleotide polymorphisms (SNPs) in the 3'-untranslated regions (3'UTR) targeted by microRNAs (miRNAs) can alter the strength of miRNA binding (and, consequently, the regulation of target genes), we wondered whether these SNPs (known as miRSNPs) affect the individual...
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