Article
Aneuploidy underlies a multicellular phenotypic switch.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 2013
Tan Zhihao, Hays Michelle, Cromie Gareth A, Jeffery Eric W, Scott Adrian C, Ahyong Vida, Sirr Amy, Skupin Alexander, Dudley Aimée M
Abstract excerpt
Although microorganisms are traditionally used to investigate unicellular processes, the yeast Saccharomyces cerevisiae has the ability to form colonies with highly complex, multicellular structures. Colonies with the "fluffy" morphology have properties reminiscent of bacterial biofilms and are easily distinguished from the "smooth" colonies typically formed by laboratory strains. We have identified strains that...
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