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Article

New associations: INFG and TGFB1 genes and the inhibitor development in severe haemophilia A.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Jul 2015

de Alencar J B, Macedo L C, de Barros M F, Rodrigues C, Shinzato A H, Pelissari C B, Machado J, Sell A M, Visentainer J E L

Abstract excerpt

INTRODUCTION: The development of factor VIII (FVIII) inhibitor is the main complication of replacement therapy in patients with haemophilia A (HA). A ratio of 5-7% of individuals HA develops antibodies (inhibitors) against the FVIII infused during the treatment, thereby reducing their pro-coagulant activity. The immunomodulatory cytokine genes have been related to the risk of development of alloantibodies in...

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Share to Blood Coagulation Factor Inhibitors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25930091
DOI: 10.1111/hae.12685

Genes

TGFB1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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