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Article

Impact of HLA alleles and cytokine polymorphisms on inhibitors development in children with severe haemophilia A.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Sept 2013

Pergantou H, Varela I, Moraloglou O, Economou M, Spanou K, Kapsimali Z, Constantinidou N, Platokouki H

Abstract excerpt

Human Leucocyte Antigen (HLA) alleles, cytokine polymorphisms and the type of factor VIII (FVIII) gene mutation are among predisposing factors for inhibitors (inh) development in children with severe haemophilia A (HA). The aim was to investigate the correlations among (i) FVIII gene intron-22 inversion, (ii) HLA alleles and haplotypes and (iii) certain cytokine polymorphisms, with the risk for FVIII inhibitors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23607306
DOI: 10.1111/hae.12168

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TNF

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