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Article

TNF‑α Gene Polymorphisms as Determinants of Alloantibody Emergence in Hemophilia: A Systematic Review and Meta-Analysis.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Jan 2026

Bezerra Alessandra Faustino da Conceição, de Sousa Natã Abner Andrade Carito, Rezende Suely Meireles, Souza Renan Pedra de

Abstract excerpt

INTRODUCTION: Inhibitor development remains one of the most serious complications of replacement therapy in patients with hemophilia. Tumour necrosis factor-alpha (TNF-α) is a key pro-inflammatory cytokine, and its genetic variants have been implicated in immune-related conditions. The association between TNF-α gene polymorphisms and inhibitor formation in hemophilia has been explored. AIM: To systematically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41653417
DOI: 10.1111/hae.70223
PMCID: PMC13175436

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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